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KMID : 0355220110360040245
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Journal of Korean Academy Oral Medicine
2011 Volume.36 No. 4 p.245 ~ p.252
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Effect of a Mouthwash Containing Cetylpyridinium and Zinc Chloride on Oral Malodor
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Kim Ju-Sik
Park Ji-Woon
Kim Dae-Jung
Kim Yeong-Gu
Lee Jeong-Yun
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Abstract
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The aim of this study is to clinically evaluate the effect of a mouthwash containing cetylpyridinium and zinc chloride on reduction of morning oral malodor in healthy subjects measured by organoleptic measurement and a portable sulfide monitor.
A total of 8 healthy non-smoking male volunteers were enrolled in this study of crossover design consisting of two experimental phases. The subjects were instructed to rinse the mouth with 10 mL of the experimental mouthwash containing cetylpyridinium and zinc chloride for 30 seconds at the first phase. At the second phase after a one-week washout period, each subject rinsed with distilled water as a control.
All experiments were conducted at around 8:30 a.m. and oral malodor was measured using organoleptic measurement and a portable sulfide monitor just before rinsing with the experimental mouthwash or control (baseline), 1 hr, 2 hrs, and 3 hrs after rinsing.
The mouthwash containing cetylpyridinium and zinc chloride reduced morning oral malodor up to 3 hrs after rinsing. Organoleptic score and concentrations of volatile sulfur compounds after use of the experimental mouthwash significantly decreased with time, and the decreases were significantly different between the mouthwash and control. In conclusion, the mouthwash containing cetylpyridinium and zinc chloride is significantly effective on reduction of morning oral malodor in healthy subjects by 3 hrs.
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KEYWORD
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Cetylpyridinium, Mouthwash, Oral malodor, Volatile sulfur compounds, Zinc chloride
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